Novel Coumarin-Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer's Disease.
Babaei E, Küçükkılınç TT, Jalili-Baleh L, Nadri H, Öz E, Forootanfar H, Hosseinzadeh E, Akbari T, Ardestani MS, Firoozpour L, Foroumadi A, Sharifzadeh M, Mirjalili BBF, Khoobi M.
Babaei E, et al.
Front Chem. 2022 Jun 30;10:895483. doi: 10.3389/fchem.2022.895483. eCollection 2022.
Front Chem. 2022.
PMID: 35844650
Free PMC article.
Compound 3f as the best AChE inhibitor (IC(50) = 2 nM) showed acceptable BuChE inhibition activity (IC(50) = 24 nM), 100 times more active than the standard drug. Compound 3f could also significantly protect PC12 and SH-SY5Y cells against H(2)O(2)-induced cell death and am …
Compound 3f as the best AChE inhibitor (IC(50) = 2 nM) showed acceptable BuChE inhibition activity (IC(50) = 24 nM), 100 times more active t …